Research

Regulation of Rho-GTPases The GTPases of the Rho family control almost every aspect of cell behavior, including cell migration, cell-cell adhesion, cell polarity, contractility, invasion, proliferation and differentiation, and gene transcription. Rho GTPases function as a link between surface receptors and the actin cytoskeleton. Activation of Rho proteins is mediated by guanine-nucleotide exchange factors (GEFs), which catalyze the exchange of GDP for GTP. However, both the identity of… More information...

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