Projects

Projects Regulation of Rho-GEFs by scaffolding proteins Sequence analysis shows that approximately half of the Rho-GEF family members contain putative binding motifs for PDZ domains in their C-terminus. PDZ domains are protein-protein interaction domains that act as scaffolds to concentrate signaling molecules at specialized regions in the cell. Our preliminary results show that these motifs in Rho-GEFs are functional and specifically bind to PDZ-containing proteins. We also found that… More information...

User:	rafaelgm
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